Piperazine (/paɪˈpɛrəziːn/) is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group.
What is the structure of piperazine?
C4H10N2Piperazine / Formula
Which drug is piperazine class?
Organic compoundPiperazine / Classification
Piperazine belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections.
Which drug contain piperazine ring?
Piperazine is a very popular motif in CNS drugs as shown in three atypical antipsychotics, one antidepressant, and one sedative hypnotic. Piperazine is also embedded in two tyrosine kinase inhibitors: imatinib (Gleevec™) and dasatinib (Sprycel™).
Which derivative is benzimidazole?
Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe. Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect.
What is piperazine derivative?
Piperazine derivatives may be found in “Ecstasy” pills as a substitute for MDMA. Metachlorophenylpiperazine (mCPP) is an indirect serotonergic antagonist but another piperazine derivative trifluoromethyl-piperazine is a direct serotonergic antagonist but both drugs do not have any dopaminergic activity.
What is the pharmacological significance of benzimidazole ring?
The benzimidazole moiety is useful for the development of novel medicinal compounds in pharmaceutical field. Benzimidazole is also a vital pharmacophore, a privileged sub-structure in medicinal chemistry which contributes as a key part for different natural activities [2].
Which anthelmintic is benzimidazole derivative?
Which is example of piperazine derivative?
The piperazine derivatives include 1-benzylpiperazine (BZP), 1,3-trifluoromethylphenylpiperazine (TFMPP), 1-(3-chlorophenyl) piperazine (mCPP) and 1-(4-methoxyphenyl) piperazine (MeOPP); a full summary of their chemical properties is presented in the ‘Physical Descriptions’ section.
